Mycoplasma genitalium Genome
Sequence Search
>Query : 281 aa
vs library
using protein matrix
174959 residues in 480 sequences
statistics exclude scores greater than 73
mean initn score: 28.3 (7.47)
mean init1 score: 27.6 (6.13)
480 scores better than 1 saved, ktup: 2, variable pamfact
joining threshold: 28
The best scores are: initn init1 opt
MG326 conserved hypothetical protein {Mycoplasma pneum 118 82 231
MG251 glycyl-tRNA synthetase {Mycoplasma pneumoniae} 67 56 60
MG450 conserved hypothetical protein {Mycoplasma pneum 63 43 82
MG292 alanyl-tRNA synthetase (alaS) {Mycoplasma pneumo 59 46 60
MG025 conserved hypothetical protein {Mycoplasma pneum 56 46 46
MG202 conserved hypothetical protein {Mycoplasma pneum 54 54 61
MG387 GTP-binding protein (era) {Mycoplasma pneumoniae 53 53 76
MG271 dihydrolipoamide dehydrogenase (pdhD) {Mycoplasm 53 32 42
MG250 DNA primase (dnaE) {Mycoplasma pneumoniae} 50 37 40
MG147 conserved hypothetical protein {Mycoplasma pneum 49 35 39
MG059 small protein (smpB) {Mycoplasma pneumoniae} 48 37 52
MG366 conserved hypothetical protein {Mycoplasma pneum 47 37 37
MG036 aspartyl-tRNA synthetase (aspS) {Mycoplasma pneu 47 37 40
MG172 methionine aminopeptidase (map) {Mycoplasma pneu 46 46 46
MG111 glucose-6-phosphate isomerase (pgi) {Mycoplasma 46 35 60
MG461 conserved hypothetical protein {Mycoplasma pneum 45 34 35
MG262 5'-3' exonuclease, putative {Mycoplasma pneumoni 45 35 35
MG335 conserved hypothetical GTP-binding protein {Myco 45 36 45
MG191 adhesin P1 (mgpB) {Mycoplasma genitalium} 45 36 36
MG242 conserved hypothetical protein {Mycoplasma pneum 45 45 47
MG051 thymidine phosphorylase (deoA) {Mycoplasma pneum 44 44 53
MG024 GTP-binding protein, putative {Mycoplasma pneumo 44 44 52
MG277 conserved hypothetical protein {Mycoplasma pneum 44 44 44
MG246 conserved hypothetical protein {Mycoplasma pneum 43 33 42
MG078 oligopeptide ABC transporter, permease protein ( 43 34 57
MG048 signal recognition particle protein (ffh) {Mycop 42 42 57
MG321 lipoprotein, putative {Mycoplasma pneumoniae} 42 32 41
MG290 ABC transporter, ATP-binding protein {Mycoplasma 42 32 42
MG145 riboflavin kinase/ FMN adenylyltransferase, puta 42 32 40
MG266 leucyl-tRNA synthetase (leuS) {Mycoplasma pneumo 41 31 39
MG073 excinuclease ABC subunit B (uvrB) {Mycoplasma pn 41 41 60
MG077 oligopeptide ABC transporter, permease protein ( 41 31 34
MG345 isoleucyl-tRNA synthetase (ileS) {Mycoplasma pne 41 31 47
MG187 ABC transporter, ATP-binding protein {Mycoplasma 41 32 40
MG210.1 conserved hypothetical protein {Mycoplasma pne 40 40 41
MG136 lysyl-tRNA synthetase (lysS) {Mycoplasma pneumon 40 40 47
MG369 conserved hypothetical protein {Mycoplasma pneum 40 31 38
MG038 glycerol kinase (glpK) {Mycoplasma pneumoniae} 40 40 53
MG261 DNA polymerase III, subunit alpha (polC-2) {Myco 39 29 49
MG096 conserved hypothetical protein {Mycoplasma pneum 39 39 48
MG378 arginyl-tRNA synthetase (argS) {Mycoplasma pneum 39 39 39
MG151 ribosomal protein L3 (rpL3) {Mycoplasma pneumoni 39 39 39
MG160 ribosomal protein S17 (rpS17) {Mycoplasma pneumo 39 39 39
MG085 hpr(ser) kinase, putative {Mycoplasma pneumoniae 39 39 51
MG063 1-phosphofructokinase (fruK) {Mycoplasma pneumon 39 39 41
MG042 spermidine/putrescine ABC transporter, ATP-bindi 39 30 50
MG372 conserved hypothetical protein {Mycoplasma pneum 38 29 53
MG379 glucose-inhibited division protein A (gidA) {Myc 38 38 47
MG208 conserved hypothetical protein {Mycoplasma pneum 38 38 42
MG278 guanosine-3',5'-bis(diphosphate) 3'- pyrophospho 38 38 43
MG326 conserved hypothetical protein {Mycoplasma pneumoniae}
25.3% identity in 289 aa overlap
10 20 30 40 50
Query MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFR-EETYREEIELDWKSFYEEVKK--HN
..:..::::: : . : . ....::::. :...:..::.:.. .. .:. :.
MG326 MKKTAIITDSTASIKPG--EINGVYILPLQVIVDGEKSFRDGIEIDYDHVHKLLKENPHG
10 20 30 40 50
60 70 80 90 100 110
Query ELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSS----AAAADSMVDNIDVY
.:: :. ..:. ..::. ..:: : ..::.:.:::.. : . .. .. .
MG326 LNISTSLPRQSDLLKIFEEIKTKYDRFIFLPLSKGLSGTYDMLVQLAKELSEQNKDKEFL
60 70 80 90 100 110
120 130 140 150 160 170
Query PFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFMVDDLAHLQRGGR
:... .. . . . .:...: .. ..: ..:. :... . ...:.....X::
MG326 VFETSDIAISLKWLVEDIKALVDKG-CDNQTIKAKVESHKQNILSAVTLKNLVQMRKGGR
120 130 140 150 160 170
180 190 200 210 220 230
Query LSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLDEDASKGLPMRAA--
.:. . ::..::.::::. :X. : . .:. . ..:...:....... ... ..
MG326 ISGLKKFITTLLRVKPIILFDKGVNTLGAKVFSFSQAVEKIFGFVKTKFGDNYKIKRIGF
180 190 200 210 220 230
240 250 260 270 280
Query --VIHANREEEAAKIIEELSAKYP---HVEFYNSYFGAVIGTHLGEGALGICWCFK
. : ..: :::... .. . :. :.....:: .: : .:..:.
MG326 CYSFCKNYANEIKKIITDFIEHNKINFQNEIENAFITSVIIVHTGIDAFSISLLIDNK
240 250 260 270 280 290
MG251 glycyl-tRNA synthetase {Mycoplasma pneumoniae}
23.3% identity in 43 aa overlap
10 20 30 40 50 60
Query DSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELDWKSFYEEVKKHNELPTTSQPPIG
..:.. . .X:... ... :: . .:..:
MG251 KKTTDFLFNFPHGLKELWGLANRGDFDLKQHQEFSKKSMSFFDSELNQHFLPFIIEPAVG
260 270 280 290 300 310
70 80 90 100 110 120
Query ELVALYEELGKSYDAVISIHLSSGISGTFSSAAAADSMVDNIDVYPFDSEISCLAQGFYA
.:. . .:X
MG251 IERLFYALIVSSYRREIINEEEREVLSLPFDLCPEQIIVLPLVNKLKKEAFSVFETLAKT
320 330 340 350 360 370
MG450 conserved hypothetical protein {Mycoplasma pneumoniae}
21.8% identity in 133 aa overlap
30 40 50 60 70 80
Query VVFREETYREEIELDWKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLS
.X::.. .:. . ... ..:: .:.:...
MG450 MINAPKGVKFSTSQTSEEEVRDKVKSIINDYDLIIGIPID
10 20 30 40
90 100 110 120 130 140
Query SGISGTFSSAAAADSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELE
..:X... . ... .. . . .:: : . .. . .::.. :.... . .
MG450 KEISTSYLNWKIVEKEFED-KFHVLDSRIVEVLIAWLISDIKVWLKNNQYSRAGLDEFVY
50 60 70 80 90
150 160 170 180 190 200
Query EMKKTVRAYFMVDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKA
..... : ..:.: .: :::::. ..:: . .: . .. :
MG450 NFRNKCGAILFVTDTKPLVAGGRLSNLKSFIIKSFKFHLLISFLGETGKLQFFNKAQSAS
100 110 120 130 140 150
210 220 230 240 250 260
Query ISRIYELLDEDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHL
MG450 SAHKLAVQFLEKKLLKKEVNFRRAALLTTMFETDKNQLIKQEFVTLLNNAVDVSEHLLSP
160 170 180 190 200 210
MG292 alanyl-tRNA synthetase (alaS) {Mycoplasma pneumoniae}
22.2% identity in 36 aa overlap
10 20 30 40 50 60
Query MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELDWKSFYEEVKKHNELPT
..X: . ......::. : . . :X.....
MG292 LVLFEKSVKNNTLTPQLTFQLNETYGFPVEIIRELVNQKGLTIDWTVFDQLMAKHRSISK
380 390 400 410 420 430
70 80 90 100 110 120
Query TSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAADSMVDNIDVYPFDSEISC
....:.
MG292 QNNQTINFEKQNINLVNFKTKSTFFYHKNKINAKVIGLFDENYLPVKELNNQSGYVVFDQ
440 450 460 470 480 490
MG025 conserved hypothetical protein {Mycoplasma pneumoniae}
18.9% identity in 37 aa overlap
130 140 150 160 170 180
Query LKAAELIKNGASSPEDIIKELEEMKKTVRAYFMVDDLAHLQRGGRLSSAQAFIGSLLKVK
X ::. ... .. :. .. .. . :.: .
MG025 SKYLFTVIIPTYNCCQYIKKALDSLLLQNEYFLKTQVLIVNDGSLDNTKEVVSDYLIKYS
10 20 30 40 50 60
190 200 210 220 230 240
Query PILHFDNKVIVPFEKIRTRKKAISRIYELLDEDASKGLPMRAAVIHANREEEAAKIIEEL
: .:.X.
MG025 NISYFEKTNGNWGSVINYVKKNKLALGQYITVLDSDDYFLKDSFKKVARFFGHDMIIGAF
70 80 90 100 110 120
MG202 conserved hypothetical protein {Mycoplasma pneumoniae}
29.8% identity in 57 aa overlap
20 30 40 50 60 70
Query EQHQIHMIPLQVVFREETYREEIELDWKSFYEEVKKHNELPTTSQPPIGELVALYEELGK
X::..: :: ...: :... :. . :X
MG202 MSEQKRRTIQIAISEDHYEELQKALELLKGTQLPFSTTVEQFVELIL
10 20 30 40
80 90 100 110 120 130
Query SYDAVISIHLSSGISGTFSSAAAADSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGA
: ...: ..:: ...:. :. ....
MG202 SNYVATSNKISSLAKSGFDVASLQQELEKIGNLSGVDDNLKGFLSELLKTSRNGFSNPNK
50 60 70 80 90 100
MG387 GTP-binding protein (era) {Mycoplasma pneumoniae}
17.2% identity in 93 aa overlap
140 150 160 170 180 190
Query GASSPEDIIKELEEMKKTVRAYFMVDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKV
:.....: . ..::.... . ...
MG387 MKVLKVGVLGPTNAGKSTLINFLHNDDSLMVSSMNNTTLLSISTEVINQANK
10 20 30 40 50
200 210 220 230 240 250
Query IVPFEKIRTRKKAISRIYELLDEDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEF
. : .... .. . X::.... .:.:. .... . :.....:^v: :... ....
MG387 NIVFIDVPGFTEKKHSNYELITKEIRKALSGIDVLLLVVRSDQNNK-IEFLKTQLQQLKR
60 70 80 90 100 110
260 270 280
Query YNSYFGAVIGTHLGEGALGICWCFK
:..
MG387 YQNLTRIFLINKFHQKSLSEVNKAIILEEFKPQKTIEINLLKFDKNLFWSIFKQVELRYN
120 130 140 150 160 170
MG271 dihydrolipoamide dehydrogenase (pdhD) {Mycoplasma pneumoniae}
16.7% identity in 30 aa overlap
10 20 30 40 50
Query MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELDWKSFYEEVKKHNE
: . .....::. : ..:... . .. . ^ ^
MG271 MDYDLIILGAGPAGYIAAEYAGKHKLKTLVIEKQYFGGVCLNVGCIPTKTLLKRAKIIDY
10 20 30 40 50 60
60 70 80 90 100 110
Query LPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAADSMVDNIDVYPFDSE
v v
MG271 LVHAKDYGITINGQAKLDWKQLLKQKQEVVDKLVAGVKTIIKGAKVESIEGEATVIDKNK
70 80 90 100 110 120
MG250 DNA primase (dnaE) {Mycoplasma pneumoniae}
28.6% identity in 28 aa overlap
20 30 40 50 60 70
Query IPKEMREQHQIHMIPLQVVFREETYREEIELDWKSFYEEVKKHNELPTTSQPPIGELVAL
.: ..X: ... :.. : . : ....:X.
MG250 IKNLVKLLEYSDEKTLYETVLKHKEKLVSKFDNNRFYINTSGHAQPPQELQKTTAALVQT
420 430 440 450 460 470
80 90 100 110 120 130
Query YEELGKSYDAVISIHLSSGISGTFSSAAAADSMVDNIDVYPFDSEISCLAQGFYALKAAE
MG250 AFEEAVNELWKPEIFAFALIDKRFLVELKQSHLDEVFKECNFNLFDVELFIEKARIYWSE
480 490 500 510 520 530
MG147 conserved hypothetical protein {Mycoplasma pneumoniae}
31.6% identity in 19 aa overlap
220 230 240 250 260 270
Query IYELLDEDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEG
.:. :.. ..X: .:X
MG147 NQTTTVVDNKPFSQLVNTKKTKWTKFFSLLVISFLCGFIEGLGFYFGYFLILGNVSSLGL
260 270 280 290 300 310
280
Query ALGICWCFK
MG147 KIYYDGLQQRDLINSSNVLFFLMTTTAIFSIKYIFEMLFFFSVEKNVVNIANHFGLY
320 330 340 350 360 370
MG059 small protein (smpB) {Mycoplasma pneumoniae}
30.8% identity in 26 aa overlap
10 20 30 40
Query MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELDW
....:. . .X: .: ::... . :X
MG059 PPYSFAGPLNHASDRIKKLLLNKHEIKQIINKKQQQSLSVIPSKVFFRNGKIKVEIWLAK
70 80 90 100 110 120
50 60 70 80 90 100
Query KSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAADSM
MG059 PKKKFDKRETIKKKTIRRELEAEYR
130 140
MG366 conserved hypothetical protein {Mycoplasma pneumoniae}
33.3% identity in 21 aa overlap
110 120 130 140 150 160
Query DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFMVD
X:::.:. . .. ......:X
MG366 LIKNNIVDLNKISDFVTKEIDSKSVRNIQPLIKNAAKIQINFWDQIQDIKKYQELKINQI
280 290 300 310 320 330
170 180 190 200 210 220
Query DLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLDEDAS
MG366 VFNYSENFDSFWSNYLLRNLIKLVFAHKYNEIFKLSGKLANWSQLTYAYKENKSITINQL
340 350 360 370 380 390
MG036 aspartyl-tRNA synthetase (aspS) {Mycoplasma pneumoniae}
25.6% identity in 43 aa overlap
110 120 130 140 150 160
Query NIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFMVDDLAHL
...: X:.. .. ..:: .. :: .
MG036 EDIVIVKAKLQRLDSVRFELINPTIKLFSKSKTPPLIIEDETDALEEVRLKYRYLDLRRR
70 80 90 100 110 120
170 180 190 200 210 220
Query QRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLDEDASKGLPM
. :: ..:X
MG036 LMQKRLLLRHQFILAIRNWFNQQGFIEIETPTLSKSTPEGAQDFLVPARIRKDCFYALVQ
130 140 150 160 170 180
MG172 methionine aminopeptidase (map) {Mycoplasma pneumoniae}
50.0% identity in 12 aa overlap
130 140 150 160 170 180
Query QGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFMVDDLAHLQRGGRLSSAQAFIGS
X :.:.::: ...X
MG172 MIYLKSANEVAGIKKACAIFKAVKAYFTIEKLLGKKLVTIDRLIKQFIEQ
10 20 30 40 50
190 200 210 220 230 240
Query LLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLDEDASKGLPMRAAVIHANREEEAAK
MG172 KQAKCAFHGYLGFPGFNCLSLNQTVIHGVADQTVFKDSDKLTLDIGIDYHGYLCDAAFTL
60 70 80 90 100 110
MG111 glucose-6-phosphate isomerase (pgi) {Mycoplasma pneumoniae}
18.1% identity in 127 aa overlap
100 110 120 130 140 150
Query SAAAADSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRA
^ ^ : . .: .v . . :v:.:. ... . ...
MG111 MFMSDKLLTIDLSHVYGFDKEIIFKKYQKKVDQIHQ
10 20 30
160 170 180 190 200 210
Query YFMVDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVI----VPFEKIRTRKKAISRI
:....::. ...:. . ... :::. .. . : . . . : .. ..:. .
MG111 DFLAHKLADGHMTGWYDQPDQNHQFLLKTINQIDKKFKSLKVTDIVYVGIGGSFTGIKTV
40 50 60 70 80 90
220 230 240 250 260 270
Query YELLDEDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGA
..:. ....:: .. ... .. .::..:.:...:
MG111 LDFLKPKQRTGLKIH--FVPDLSAFQAASVIKEIKNKSWALITTSKSGRTLEPALNFRIF
100 110 120 130 140 150
280
Query LGICWCFK
MG111 RNLLNKRYGNKHYQRVVVITDEKKGLLTKMASNHGYQKLVIDSNIGGRFSTLSPAGLLLA
160 170 180 190 200 210
MG461 conserved hypothetical protein {Mycoplasma pneumoniae}
36.4% identity in 11 aa overlap
230 240 250 260 270 280
Query SKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGICWCFK
X: . .. :X.
MG461 ILNSSAFLNIDQIKKQTVLVAGLLHDLGHGPHSHAFEIYFAKNPDFKKQLFIHEKVTSML
70 80 90 100 110 120
MG461 VNSEPIVSILKANKIDPNLIGALIDENQNIQPINWWMRQLISSDLDTDRMDYLLRDAYFT
130 140 150 160 170 180
MG262 5'-3' exonuclease, putative {Mycoplasma pneumoniae}
27.6% identity in 29 aa overlap
130 140 150 160 170 180
Query YALKAAELIKNGASSPEDIIKELEEMKKTVRAYFMVDDLAHLQRGGRLSSAQAFIGSLLK
X::: . . .. .. ..:. ..:. . :X.
MG262 MKKAILIDGNSLAYRAYFATWKQVEYAKQNNLPFNNAIRTMLLM
10 20 30 40
190 200 210 220 230 240
Query VKPILHFDNKVIVPFEKIRTRKKAISRIYELLDEDASKGLPMRAAVIHANREEEAAKIIE
MG262 CWNLIKANVYQYGIVSFDTKAPTFRDQIYEGYKQKRVKTPVELLVQIPLIKQALVYLGFL
50 60 70 80 90 100
MG335 conserved hypothetical GTP-binding protein {Mycoplasma pneumoniae}
19.3% identity in 88 aa overlap
110 120 130 140 150 160
Query DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFMVD
....:. . .: ...... ....
MG335 AKINKNKKDFITNLLTQFLNFRSNLVGVVLIVDSGVVTVQDQEVVKIILQTGLNFLIVAN
80 90 100 110 120 130
170 180 190 200 210 220
Query DLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLDEDAS
....:....: : .. :...::: .X:. :... .. .. . ..:.::. :X.
MG335 KFDKLNQSERYFSLKN-IANFLKV----NFDKCVFASTKTHHNLALVHKKIFELFVEDER
140 150 160 170 180 190
230 240 250 260 270 280
Query KGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGICWCFK
MG191 adhesin P1 (mgpB) {Mycoplasma genitalium}
50.0% identity in 12 aa overlap
10 20 30 40
Query MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREE
X: ::... .:X
MG191 TAALTLGVITGVGGYFLFNQNKQRSSVSNFAYQPKQLSVKHQQAVDETLTPWTWNNNNFS
20 30 40 50 60 70
50 60 70 80 90 100
Query IELDWKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAA
MG191 SLKITGENPGSFGLVRSQNDNLNISSVTKNSSDDNLKYLNAVEKYLDGQQNFAIRRYDNN
80 90 100 110 120 130
MG242 conserved hypothetical protein {Mycoplasma pneumoniae}
15.9% identity in 63 aa overlap
100 110 120 130 140 150
Query SGTFSSAAAADSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMK
. X:.:.. . :.. .: ... ...::X
MG242 IEFDLYEKGFDKSHFSRNIALLESLSFSWLDPFYGLTSIKEIMQKIDSKSNLKTSIEEMV
490 500 510 520 530 540
160 170 180 190 200 210
Query KTVRAYFMVDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISR
. . .... .. . .. .::. ....
MG242 NRFKHEQRINKKDNERVLMIFAYIAAFVVGFINFFSMVFTILTVSDLNAGLTVPNIIVIS
550 560 570 580 590 600
220 230 240 250 260 270
Query IYELLDEDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEG
MG242 IASVLAFILIVIAVLFRFKWKHIKH
610 620 630
 |
| |
|
|
|
|
